BAI, a 3-aminoindazole derivative, inhibits interleukin-1β-induced expression of cyclooxygenase-2 in A549 human airway cells
نویسندگان
چکیده
منابع مشابه
–Induced Cyclooxygenase-2 Expression in Human Airway Smooth-Muscle Cells
We studied the effect of endogenous and exogenous prostaglandin E 2 (PGE 2 ), a metabolite of arachidonic acid through the cyclooxygenase (COX) pathway, on interleukin (IL)-1 b –induced COX-2 expression, using primary cultures of human bronchial smooth-muscle cells (HBSMC). Treatment with exogenous PGE 2 resulted in enhanced expression of IL-1 b –induced COX-2 protein and messenger RNA (mRNA) a...
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In this study, we evaluated the role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the tumor necrosis factor-alpha (TNF-alpha) induced cyclooxygenase-2 (COX-2) expression using A549 lung adenocarcinoma cells. TNF-alpha induced the expression of COX-2 in A549 cells, but did not induce BEAS-2B expression. The expression of COX-2 in A549 cells was TNF-alpha dose-dependent (5~100...
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Prostanoids are important regulators of ovarian function, especially during ovulation and luteolysis. Cyclooxygenase (Cox) is the rate-limiting enzyme in conversion of arachidonic acid to prostanoids. We have examined the expression and regulation of the inducible Cox isoform (Cox-2) and of the receptor for PGF2alpha (FP) in human granulosa cells obtained from women undergoing oocyte retrieval ...
متن کاملCpG DNA modulates interleukin 1β-induced interleukin-8 expression in human bronchial epithelial (16HBE14o-) cells
BACKGROUND Recognition of repeat unmethylated CpG motifs from bacterial DNA through Toll-like receptor (TLR-9) has been shown to induce interleukin (IL)-8 expression in immune cells. We sought to investigate the role of CpG oligodeoxynucleotides (ODN) on a human bronchial epithelial cells. METHODS RT-PCR and Western blot analysis were used to determine expression of TLR-9 in human bronchial e...
متن کاملDexamethasone Inhibits Interleukin-1β-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells
OBJECTIVES To investigate the effect of interleukin (IL)-1β on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1β-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved. METHODS House ear institute-organ of Corti 1 (HEI-OC1) cells were used and exposed to IL-1β with/without dexamethasone. Glucocorticoid receptor antagonist, R...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2011
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2011.863